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There’s nothing wrong with wanting a clean kill. Most of us who’ve hunted long enough value a cartridge that puts game down quickly and ethically. But there’s a line between fast kills and unnecessary destruction. Some calibers cross that line—leaving bloodshot shoulders, shredded ribs, and wasted meat that should’ve ended up on your table. Bigger and faster doesn’t always mean better. If your freezer’s light after a successful hunt, your cartridge might be to blame. It pays to know which rounds tend to ruin meat, especially if you’re hunting for food, not trophies.

.300 Remington Ultra Magnum

There’s no denying the .300 RUM brings serious power, but it’s like trying to kill a squirrel with a sledgehammer when you use it on deer. The velocity alone is enough to tear up everything between the entrance and exit. Even a double-lung shot can leave the front quarters trashed if you’re too close. If you’re shooting elk at long range, it has a place. But inside 200 yards on whitetails? You’ll spend more time trimming bloodshot meat than you will wrapping steaks.

.243 Winchester with varmint bullets

WholesaleHunter/GunBroker

The .243 can be great on deer—when it’s loaded right. But too many hunters grab lightweight varmint loads and expect them to hold together on a whitetail. They don’t. These bullets explode on impact, destroying shoulder meat and sometimes failing to penetrate well. You’re left with a mess up front and not much of a blood trail if the shot isn’t perfect. It’s not the caliber’s fault—it’s the ammo. If you hunt with a .243, pick a proper big-game bullet or you’re going to ruin more meat than you pack out.

.30-06 Springfield with light soft points

The old ought-six can handle everything on this continent, but bullet choice matters. When you pair it with a soft 150-grain deer round and hit a shoulder, the result is usually bloodshot soup. That front quarter’s done. The .30-06 has enough punch that a harder bullet or a heavier load is often the better option. You don’t need a grenade going off on impact. If your rifle’s tuned and your aim’s steady, there’s no reason to waste half the deer because your ammo grenades on the first rib.

.270 Winchester at close range

AmmoForSale.com

A lot of folks love their .270s, and for good reason—it’s flat, accurate, and hard-hitting. But at close range, that speed works against you. I’ve seen lung shots blow out ribs and leave an exit hole big enough to fit a soda can through. It’s not always a shoulder shot that causes damage either—it’s the velocity doing the work. If you’re shooting deer at 60 yards with hot factory loads, expect to lose some meat. Step back a bit or slow it down, and it behaves better.

7mm Remington Magnum

The 7 Mag is popular for a reason—it carries energy well, shoots flat, and has plenty of punch for elk. But it can be downright destructive on deer. Hit the shoulder, and you’re likely to waste both sides. Even a good lung shot can leave an impressive exit wound that ruins nearby meat. If you’re hunting in thick timber or at short distances, you’re better off with something that won’t blow through like a wrecking ball. This round shines at 300 yards—not at 75.

.338 Winchester Magnum

MidwayUSA

If you want to anchor a moose, the .338 Win Mag does the job. But on anything smaller, you’re going to turn good meat into scraps if you’re not careful. It’s too much gun for deer and borderline for elk at close range unless you’re really confident in your shot placement. I’ve seen a pass-through shoulder hit leave nothing salvageable up front. You might drop the animal where it stands, but you’ll also leave a pile of wasted protein in the field. That’s a lousy tradeoff for most hunters.

.223 Remington with rapid-expanding bullets

There’s always debate about using .223 on deer. It can work, but the margin for error is slim. And when hunters go for high-velocity varmint loads, they get disaster. Those bullets are built to fragment on coyotes—not punch through a whitetail’s chest. The result? Surface wounds, bloodshot meat, and a poor recovery rate. Even when it does connect cleanly, the damage to edible cuts can be worse than with larger calibers. If you’re going to use .223 legally on deer, use a bonded bullet built for penetration—not splatter.

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Here’s more from us:
Calibers That Shouldn’t Even Be On the Shelf Anymore
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*This article was developed with AI-powered tools and has been carefully reviewed by our editors.

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